Transforming growth factor-beta: recent progress and new challenges.
نویسندگان
چکیده
منابع مشابه
Transforming growth factor-beta: recent progress and new challenges
I T is just 10 years since the peptide, transforming growth factor-/31 (TGF-~I) 1, was isolated from human platelets, human placenta, and bovine kidney and characterized as a discrete molecular entity, namely a 25-kD homodimer with a unique NH2-terminal sequence. Two years later this molecule was cloned, and subsequently four other closely related isoforms have been found in vertebrates; three ...
متن کاملTransforming Growth Factor-fl: Recent Progress and New Challenges
I T is just 10 years since the peptide, transforming growth factor-/31 (TGF-~I) 1, was isolated from human platelets, human placenta, and bovine kidney and characterized as a discrete molecular entity, namely a 25-kD homodimer with a unique NH2-terminal sequence. Two years later this molecule was cloned, and subsequently four other closely related isoforms have been found in vertebrates; three ...
متن کاملThe Role of Transforming Growth Factor Beta 1 (TGFβ1) in Nasal and Paranasal Sinuses Polyposis
Background and Objectives: Nasal polyposis is a diseases resulting from complex pathogenetic mechanisms. Some studies showed that TGFβ1 had significant role in this pathogenesis. In this study, we investigated the roe of cytokines and mediators in polyp development. Material and Methods: In this case- control study, healthy nasal mucosal samples were obtained from 24 peopl...
متن کاملTransforming growth factor-beta and fibrosis.
Transforming growth factor-beta (TGF-beta), a prototype of multifunctional cytokine, is a key regulator of extracellular matrix (ECM) assembly and remodeling. Specifically, TGF-beta isoforms have the ability to induce the expression of ECM proteins in mesenchymal cells, and to stimulate the production of protease inhibitors that prevent enzymatic breakdown of the ECM. Elevated TGF-beta expressi...
متن کاملTransforming growth factor beta inhibits megakaryocyte growth and endomitosis.
Using a rat bone marrow culture system, the effect of transforming growth factor beta 1 (TGF beta 1) on megakaryocyte growth and endoreduplication has been studied. Purified human platelet TGF beta 1 inhibited the number of megakaryocytes that appeared in culture at a half-maximal concentration of 0.66 +/- 0.21 ng/mL and inhibited megakaryocyte endoreduplication at a half-maximal concentration ...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Journal of Cell Biology
سال: 1992
ISSN: 0021-9525,1540-8140
DOI: 10.1083/jcb.119.5.1017